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Visualizzazione post con etichetta virus. Mostra tutti i post
Visualizzazione post con etichetta virus. Mostra tutti i post

lunedì 19 aprile 2021

«Cinese» e «Spagnola». Una tempesta di citochine e un virus (quasi) innocente! Le proteine killers di Vincenzo Dell'Aria

 

 

I coronavirus pandemici non differiscono fra loro in quanto a virulenza ma per una diversa vivacità nello stimolare l’apparato immunologico a produrre il loro arsenale bellico di citochine, le “proteine killers”. Se per il covid 19 si stabilisce il cortisone quale terapia elettiva e si abolisce quella impropria, deleteria e, purtroppo, protocollare eparinica, la mortalità potrebbe scendere nei limiti fisiopatologici di una normale pandemia. Allora l’attuale strategia anti virale andrebbe rivista dando al virus la tolleranza, che nei secoli ha sempre goduta nelle pandemie, affinché la fisiologica maturazione del pool anticorpale delle popolazioni lo possa meglio controllare ed alla fine eliminarlo. Ed è questo che sempre è avvenuto per il passato e, si spera, avverrà in futuro senza le mascherine, i tamponi e la segregazione.

martedì 23 marzo 2021

The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race by Walter Isaacson

 

 

The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.

When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.

Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.

Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?

After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.

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